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acute myeloid leukemia 2

epigenetics 2

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TLR4 transgenic ewe 1

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Association of gene variants with juvenile amyotrophic lateral sclerosis

Frontiers of Medicine doi: 10.1007/s11684-023-1005-y

Abstract: Amyotrophic lateral sclerosis (ALS) is a fatal neurodegenerative disease characterized by progressive degeneration of motor neurons, and it demonstrates high clinical heterogeneity and complex genetic architecture. A variation within TRMT2B (c.1356G>T; p.K452N) was identified to be associated with ALS in a family comprising two patients with juvenile ALS (JALS). Two missense variations and one splicing variation were identified in 10 patients with ALS in a cohort with 910 patients with ALS, and three more variants were identified in a public ALS database including 3317 patients with ALS. A decreased number of mitochondria, swollen mitochondria, lower expression of ND1, decreased mitochondrial complex I activities, lower mitochondrial aerobic respiration, and a high level of ROS were observed functionally in patient-originated lymphoblastoid cell lines and TRMT2B interfering HEK293 cells. Further, TRMT2B variations overexpression cells also displayed decreased ND1. In conclusion, a novel JALS-associated gene called TRMT2B was identified, thus broadening the clinical and genetic spectrum of ALS.

Keywords： TRMT2B     amyotrophic lateral sclerosis     mitochondrial complex I     tRNA methylation     reactive oxygen    

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Shape selective catalysis in methylation of toluene: Development, challenges and perspectives

Jian Zhou, Zhicheng Liu, Yangdong Wang, Dejin Kong, Zaiku Xie

Frontiers of Chemical Science and Engineering 2018, Volume 12, Issue 1,   Pages 103-112 doi: 10.1007/s11705-017-1671-x

Abstract: Toluene methylation with methanol offers an alternative method to produce -xylene by gathering methylrealize directional conversion of toluene/methanol molecules by selective catalysis in complicated methylationIn this review, we introduce the synthesis method of -xylene, the development history of methylationconstructing -xylene as the single target product, the major challenge to develop -selective toluene methylationTo reach higher yield of -xylene and more methanol usage in methylation, zeolite catalyst design should

Keywords： shape selective catalysis     methylation of toluene    

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Environmental pollution and DNA methylation: carcinogenesis, clinical significance, and practical applications

Yi Cao

Frontiers of Medicine 2015, Volume 9, Issue 3,   Pages 261-274 doi: 10.1007/s11684-015-0406-y

Abstract: Studies on DNA methylation are among the earliest and most conducted epigenetic research linked to cancerIn this review, the roles of DNA methylation in carcinogenesis and their significance in clinical medicinewere summarized, and the effects of environmental pollutants, particularly air pollutants, on DNA methylationFurthermore, prospective applications of DNA methylation to environmental pollution detection and cancer

Keywords： environmental pollution     DNA methylation     cancer     biomarker     diagnosis     therapy     prevention    

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DNA methylation-based subclassification of psoriasis in the Chinese Han population

Fusheng Zhou, Changbing Shen, Yi-Hsiang Hsu, Jing Gao, Jinfa Dou, Randy Ko, Xiaodong Zheng, Liangdan Sun, Yong Cui, Xuejun Zhang

Frontiers of Medicine 2018, Volume 12, Issue 6,   Pages 717-725 doi: 10.1007/s11684-017-0588-6

Abstract: Previous studies on DNA methylation (DNAm) found genetic markers that are closely associated with Ps,

Keywords： psoriasis     DNA methylation     subclassification    

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Mutant DNA methylation regulators endow hematopoietic stem cells with the preleukemic stem cell property

Yuting Tan,Han Liu,Saijuan Chen

Frontiers of Medicine 2015, Volume 9, Issue 4,   Pages 412-420 doi: 10.1007/s11684-015-0423-x

Abstract:

Genetic mutations are considered to drive the development of acute myeloid leukemia (AML). With the rapid progress in sequencing technologies, many newly reported genes that are recurrently mutated in AML have been found to govern the initiation and relapse of AML. These findings suggest the need to distinguish the driver mutations, especially the most primitive single mutation, from the subsequent passenger mutations. Recent research on DNA methyltransferase 3A (DNMT3A) mutations provides the first proof-of-principle investigation on the identification of preleukemic stem cells (pre-LSCs) in AML patients. Although DNMT3A mutations alone may only transform hematopoietic stem cells into pre-LSCs without causing the full-blown leukemia, the function of this driver mutation appear to persist from AML initiation up to relapse. Therefore, identifying and targeting preleukemic mutations, such as DNMT3A mutations, in AML is a promising strategy for treatment and reduction of relapse risk.

Keywords： preleukemic stem cell     acute myeloid leukemia     relapse     DNMT3A    

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The value of epigenetic markers in esophageal cancer

Xiao-Mei ZHANG, Ming-Zhou GUO,

Frontiers of Medicine 2010, Volume 4, Issue 4,   Pages 378-384 doi: 10.1007/s11684-010-0230-3

Abstract: In addition to genetic alteration, epigenetic modifications, and in particular DNA methylation, are recognizedIn esophageal cancer, aberrant methylation of promoter regions occurs not only in advanced cancer, butDNA methylation is related to survival time and sensitivity of chemoradiotherapy.

Keywords： epigenetics     DNA methylation     esophageal cancer     dysplasia    

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The critical importance of epigenetics in autoimmune-related skin diseases

Frontiers of Medicine 2023, Volume 17, Issue 1,   Pages 43-57 doi: 10.1007/s11684-022-0980-8

Abstract: The most important epigenetic mechanisms are DNA methylation, histone modification, and noncoding RNAs

Keywords： epigenetics     autoimmune-related skin diseases     DNA methylation     histone modifications     noncoding RNAs    

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5′-tiRNA-Gln inhibits hepatocellular carcinoma progression by repressing translation through the interaction with eukaryotic initiation factor 4A-I

Frontiers of Medicine 2023, Volume 17, Issue 3,   Pages 476-492 doi: 10.1007/s11684-022-0966-6

Abstract: tRNA-derived small RNAs (tsRNAs) are novel non-coding RNAs that are involved in the occurrence and progressionA novel tsRNA, tRNAGln-TTG derived 5′-tiRNA-Gln, is significantly downregulated, and its expression

Keywords： EIF4A1     G-quadruplex     hepatocellular carcinoma     tRNA-derived small RNA     translation initiation    

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Accurate quantification of 3′-terminal 2′-O-methylated small RNAs by utilizing oxidative deep sequencing and stem-loop RT-qPCR

Frontiers of Medicine 2022, Volume 16, Issue 2,   Pages 240-250 doi: 10.1007/s11684-021-0909-7

Abstract: (miRNAs) and Piwi-interacting RNAs (piRNAs), are modified at their 3′-terminal nucleotides via 2′-O-methylationHowever, quantifying the levels of these small RNAs is difficult because 2′-O-methylation at the RNAAccurate measurement of the 3′-terminal 2′-O-methylation of small RNAs has profound implications for

Keywords： small RNAs     2′-O-methylation     sequencing     RT-qPCR    

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Distinct gene expression pattern of mutations coordinated by target repression and promoter hypermethylation in acute myeloid leukemia

Frontiers of Medicine 2022, Volume 16, Issue 4,   Pages 627-636 doi: 10.1007/s11684-020-0815-4

Abstract: Through the integration of DNA methylation array data, we illustrated that hypermethylation on the promoter

Keywords： RUNX1     gene mutation     acute myeloid leukemia     transcriptional repression     DNA methylation    

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Effects of the

Yi FANG,Xiangwei FU,Junjie LI,Ming DU,Baoyu JIA,Jinlong ZHANG,Xiaosheng ZHANG,Shien ZHU

Frontiers of Agricultural Science and Engineering 2014, Volume 1, Issue 4,   Pages 314-320 doi: 10.15302/J-FASE-2014038

Abstract: F ) and their positive offspring (F ), hematological and reproductive parameters and the global DNA methylationAdditionally, no significant differences were found between transgenic and wild-type ewes in the DNA methylation

Keywords： TLR4 transgenic ewe     safety assessment     reproductive trait     oocyte     DNA methylation    

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Effects of hydralazine and valproate on the expression of E-cadherin gene and the invasiveness of QBC

Hong LI, Shaoqin CHEN, Yi SHU, Yongjun CHEN, Ying SU, Xin WANG, Shengquan ZOU

Frontiers of Medicine 2009, Volume 3, Issue 2,   Pages 153-157 doi: 10.1007/s11684-009-0034-5

Abstract: To clarify the effect of DNA methylation and histone deacetylase inhibitors on the expression of theThe methylation status of the promoter region of the gene was detected with methylation-specific PCRHowever, the methylation status of the gene could be thoroughly reversed by using valproate and hydralazine

Keywords： DNA methylation inhibitor     histone deacetylase inhibitor     bile duct carcinoma     E-cadherin    

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Title Author Date Type Operation

Association of gene variants with juvenile amyotrophic lateral sclerosis

Journal Article

Shape selective catalysis in methylation of toluene: Development, challenges and perspectives

Jian Zhou, Zhicheng Liu, Yangdong Wang, Dejin Kong, Zaiku Xie

Journal Article

Environmental pollution and DNA methylation: carcinogenesis, clinical significance, and practical applications

Yi Cao

Journal Article

DNA methylation-based subclassification of psoriasis in the Chinese Han population

Fusheng Zhou, Changbing Shen, Yi-Hsiang Hsu, Jing Gao, Jinfa Dou, Randy Ko, Xiaodong Zheng, Liangdan Sun, Yong Cui, Xuejun Zhang

Journal Article

Mutant DNA methylation regulators endow hematopoietic stem cells with the preleukemic stem cell property

Yuting Tan,Han Liu,Saijuan Chen

Journal Article

The value of epigenetic markers in esophageal cancer

Xiao-Mei ZHANG, Ming-Zhou GUO,

Journal Article

The critical importance of epigenetics in autoimmune-related skin diseases

Journal Article

5′-tiRNA-Gln inhibits hepatocellular carcinoma progression by repressing translation through the interaction with eukaryotic initiation factor 4A-I

Journal Article

Accurate quantification of 3′-terminal 2′-O-methylated small RNAs by utilizing oxidative deep sequencing and stem-loop RT-qPCR

Journal Article

Distinct gene expression pattern of mutations coordinated by target repression and promoter hypermethylation in acute myeloid leukemia

Journal Article

Effects of the

Yi FANG,Xiangwei FU,Junjie LI,Ming DU,Baoyu JIA,Jinlong ZHANG,Xiaosheng ZHANG,Shien ZHU

Journal Article

Effects of hydralazine and valproate on the expression of E-cadherin gene and the invasiveness of QBC

Hong LI, Shaoqin CHEN, Yi SHU, Yongjun CHEN, Ying SU, Xin WANG, Shengquan ZOU

Journal Article